Primary Retention of Molars and RANKL Signaling Alteration during Craniofacial Growth
Open Access
- 24 March 2020
- journal article
- research article
- Published by MDPI AG in Journal of Clinical Medicine
- Vol. 9 (4), 898
- https://doi.org/10.3390/jcm9040898
Abstract
The primary retention of molars observed in clinic corresponds to a still-unexplained absence of molar eruption despite the presence of an eruption pathway, resembling the experimental transient inhibition of RANKL signaling in mice. The aim of the present study was to confront the hypothesis according to which the primary retention of molars is associated with transitory perturbations to RANKL signaling during growth as part of a wider craniofacial skeleton pattern. The experimental strategy was based on combining a clinical study and an animal study corresponding to the characterization of the craniofacial phenotypes of patients with primary retention of molars and analyses in mice of the consequences of transient inhibition of RANKL signaling on molar eruption and craniofacial growth. The clinical study validated the existence of a particular craniofacial phenotype in patients with primary retention of molars: a retromandibular skeletal class II typology with reduced mandibular dimensions which manifests itself at the dental level by a class II/2 with palatoversion of the upper incisors and anterior overbite. The animal study demonstrated that transient invalidation of RANKL signaling had an impact on the molar eruption process, the severity of which was dependent on the period of inhibition and was associated with a reduction in two craniofacial morphometric parameters: total skull length and craniofacial vault length. In conclusion, primary retention of molars may be proposed as part of the craniofacial skeleton phenotype associated with a transitory alteration in RANKL signaling during growth.Funding Information
- Inserm (Recurent funding)
This publication has 33 references indexed in Scilit:
- Role of RANKL (TNFSF11)-Dependent Osteopetrosis in the Dental Phenotype of Msx2 Null Mutant MicePLOS ONE, 2013
- Osteoclasts in the Dental Microenvironment: A Delicate Balance Controls Dental HistogenesisCells Tissues Organs, 2011
- Exome resequencing combined with linkage analysis identifies novel PTH1R variants in primary failure of tooth eruption in JapaneseJournal of Bone and Mineral Research, 2011
- Bone resorption control of tooth eruption and root morphogenesis: Involvement of the receptor activator of NF‐κB (RANK)Journal of Cellular Physiology, 2010
- Dlx homeobox gene family expression in osteoclastsJournal of Cellular Physiology, 2010
- Editor's Summary and Q&A: Primary failure of eruption and PTH1R: The importance of a genetic diagnosis for orthodontic treatment planningAmerican Journal of Orthodontics and Dentofacial Orthopedics, 2010
- Primary failure of eruption and PTH1R: The importance of a genetic diagnosis for orthodontic treatment planningAmerican Journal of Orthodontics and Dentofacial Orthopedics, 2010
- Delayed tooth eruption: Pathogenesis, diagnosis, and treatment. A literature reviewAmerican Journal of Orthodontics and Dentofacial Orthopedics, 2004
- Opg, Rank,andRanklin Tooth Development: Co-ordination of Odontogenesis and OsteogenesisJournal of Dental Research, 2004
- Eruption disturbances of permanent molars: a reviewJournal of Oral Pathology & Medicine, 1991