Do late and early onset depression differ in terms of inflammation?

Abstract

Objective: To compare neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), and monocyte-lymphocyte ratio (MLR) values as inflammation markers in patients with early- and late-onset geriatric depression. Method: Patients aged 60 or over and hospitalized due to depressive disorder between 01.01.2012 and 01.01.2020 were included in this retrospective record review study. Only patients with unipolar depression were included. Results: No difference in terms of NLO, PLO or MLO was found between early- and lateonset depression. However, NLO and PLO values were higher in the early- and late-onset depression groups than in the control group. Lymphocyte and monocyte counts were higher in the control group than in the early- and late-onset depression groups. Conclusion: NLO and PLO may be regarded as markers reflecting inflammation in geriatric depression patients rather than as markers capable of differentiating geriatric depression patients in terms of disease onset time.