Neuronal electrical activity induced by optical trapping of neurotransmitter receptors on neuron

Abstract

AMPA-type glutamate receptor (AMPAR) is one of neurotransmitter receptors at excitatory synapses in neuronal cell. For realizing the artificial control of synaptic transmission, we have applied optical trapping of quantum-dot (QD) conjugated AMPARs on neuronal cells. Here, we demonstrate simultaneous measurement combined with optical trapping and patch-clamp recordings to evaluate the neuronal electrical activity. The relationship between optical trapping dynamics of QD-AMPARs located on neuronal cells and the neuronal electrical activity was discussed.