A versatile and multifunctional metal–organic framework nanocomposite toward chemo-photodynamic therapy
- 26 March 2020
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Dalton Transactions
- Vol. 49 (16), 5291-5301
- https://doi.org/10.1039/c9dt04804a
Abstract
Previously most of the applications of targeting components have been based on the enhanced permeability and retention effect achieved using folic acid, which consider the side effects of the targeting components to some extent. Herein, we report a new strategy to decorate the surface of MOFs using a pemetrexed (MTA) targeting molecule, affording a new drug delivery system of ALA@UIO-66-NH-FAM/MTA (ALA = 5-amino-levulinic acid and FAM = 5-carboxyfluorescein). The confocal microscopy and flow cytometry results showed that ALA@UIO-66-NH-FAM/MTA presented a better targeting effect compared to ALA@UIO-66-NH-FAM/FA (FA = folic acid) and indicated a gradually increasing tendency of the targeting effect with the increasing expression of folate receptors on the tumor cell cytomembrane. Furthermore, the cytotoxicity experiment indicates that the combination of chemotherapy and photodynamic therapy is a more effective therapy model than single chemotherapy and photodynamic therapy. This work demonstrates the first attempt at folic acid antagonist (MTA) modification for NMOFs, providing a new concept for the design of MOFs with folate receptor targeting capacity for clinical applications.Keywords
Funding Information
- National Natural Science Foundation of China (51978415)
- Shenzhen Peacock Plan (KQTD2016022920325195)
This publication has 71 references indexed in Scilit:
- A new copper-based metal–organic framework as a promising heterogeneous catalyst for chemo- and regio-selective enamination of β-ketoestersChemical Communications, 2013
- A Series of Heterometallic Three-Dimensional Frameworks Constructed from Imidazole–Dicarboxylate: Structures, Luminescence, and Magnetic PropertiesCrystal Growth & Design, 2013
- Structural basis for molecular recognition of folic acid by folate receptorsNature, 2013
- Rationale of Drug Encapsulation and Release from Biocompatible Porous Metal–Organic FrameworksChemistry of Materials, 2013
- Towards an Improved anti‐HIV Activity of NRTI via Metal–Organic Frameworks NanoparticlesAdvanced Healthcare Materials, 2013
- Antifolates in cancer therapy: Structure, activity and mechanisms of drug resistanceDrug Resistance Updates, 2012
- Synthesis of core–shell coordination polymer nanoparticles (CPNs) for pH-responsive controlled drug releaseChemical Communications, 2012
- The Biocompatibility of Metal–Organic Framework Coatings: An Investigation on the Stability of SURMOFs with Regard to Water and Selected Cell Culture MediaLangmuir, 2012
- Lipid-coated nanoscale coordination polymers for targeted delivery of antifolates to cancer cellsChemical Science, 2011
- Autophagy in tumorigenesis and energy metabolism: friend by day, foe by nightCurrent Opinion in Genetics & Development, 2011