Tumor-infiltrating dendritic cell states are conserved across solid human cancers
Open Access
- 18 December 2020
- journal article
- review article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 218 (1)
- https://doi.org/10.1084/jem.20200264
Abstract
Dendritic cells (DCs) contribute a small fraction of the tumor microenvironment but are emerging as an essential antitumor component based on their ability to foster T cell immunity and immunotherapy responses. Here, we discuss our expanding view of DC heterogeneity in human tumors, as revealed with meta-analysis of single-cell transcriptome profiling studies. We further examine tumor-infiltrating DC states that are conserved across patients, cancer types, and species and consider the fundamental and clinical relevance of these findings. Finally, we provide an outlook on research opportunities to further explore mechanisms governing tumor-infiltrating DC behavior and functions.Keywords
Funding Information
- Massachusetts General Hospital
- National Institutes of Health (R01-AI084880, R01-CA206890, NIH-U01-CA224348, P01-CA240239, R01-CA218579)
- Swiss National Science Foundation (P400PM_183852)
- ISREC Foundation
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