Voltammetric sensor based on bimetallic nanocomposite for determination of favipiravir as an antiviral drug
- 27 November 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Microchimica Acta
- Vol. 188 (12), 1-15
- https://doi.org/10.1007/s00604-021-05107-2
Abstract
A novel and sensitive voltammetric nanosensor was developed for the first time for trace level monitoring of favipiravir based on gold/silver core–shell nanoparticles (Au@Ag CSNPs) with conductive polymer poly (3,4-ethylene dioxythiophene) polystyrene sulfonate (PEDOT:PSS) and functionalized multi carbon nanotubes (F-MWCNTs) on a glassy carbon electrode (GCE). The formation of Au@Ag CSNPs/PEDOT:PSS/F-MWCNT composite was confirmed by various analytical techniques, including X-ray diffraction (XRD), ultraviolet–visible spectroscopy (UV–Vis), transmission electron microscopy (TEM), energy-dispersive X-ray spectroscopy (EDX), and field-emission scanning electron microscopy (SEM). Under the optimized conditions and at a typical working potential of + 1.23 V (vs. Ag/AgCl), the Au@Ag CSNPs/PEDOT:PSS/F-MWCNT/GCE revealed linear quantitative ranges from 0.005 to 0.009 and 0.009 to 1.95 µM with a limit of detection 0.46 nM (S/N = 3) with acceptable relative standard deviations (1.1-4.9 %) for pharmaceutical formulations, urine, and human plasma samples without applying any sample pretreatment (1.12–4.93%). The interference effect of antiviral drugs, biological compounds, and amino acids was negligible, and the sensing system demonstrated outstanding reproducibility, repeatability, stability, and reusability. The findings revealed that this assay strategy has promising applications in diagnosing FAV in clinical samples, which could be attributed to the large surface area on active sites and high conductivity of bimetallic nanocomposite. Graphical abstractKeywords
Funding Information
- Ankara Universitesi (21B0237005)
This publication has 72 references indexed in Scilit:
- Study on the applicability of polytetrafluoroethylene–silver composite thin films as sensor materialApplied Surface Science, 2013
- Polymer thin films embedded with metal nanoparticles for electrochemical biosensors applicationsBiosensors and Bioelectronics, 2013
- Preparation and properties of chitosan nanocomposite films reinforced by poly(3,4-ethylenedioxythiophene)-poly(styrenesulfonate) treated carbon nanotubesMaterials Chemistry and Physics, 2011
- N‐(3,4‐Dihydroxyphenethyl)‐3,5‐dinitrobenzamide‐Modified Multiwall Carbon Nanotubes Paste Electrode as a Novel Sensor for Simultaneous Determination of Penicillamine, Uric acid, and TryptophanElectroanalysis, 2011
- On the Influence of Silver Nanoparticles Size in the Electrical Conductivity of PEDOT: PSSMaterials Science Forum, 2010
- Innate immune evasion strategies of influenza virusesFuture Microbiology, 2010
- Conductivity, work function, and environmental stability of PEDOT:PSS thin films treated with sorbitolOrganic Electronics, 2008
- Near-Infrared Resonant Nanoshells for Combined Optical Imaging and Photothermal Cancer TherapyNano Letters, 2007
- Electrochemical sensors based on conducting polymer—polypyrroleElectrochimica Acta, 2006
- On the mechanism of conductivity enhancement in poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) film through solvent treatmentPolymer, 2004