Meniscectomy-induced osteoarthritis in the sheep model for the investigation of therapeutic strategies: a systematic review

Abstract
One of the major risk factors for OA is meniscectomy (Mx) that causes a rapid and progressive OA. Mx has been employed in various animal models, especially in large ones, to study preclinical safety and strategy effectiveness to counteract OA. The aim of the present study is to review in vivo studies, performed in sheep and published in the last ten years.