Combined Small and Squamous Transformation in EGFR-mutated Lung Adenocarcinoma
Open Access
- 15 May 2020
- journal article
- research article
- Published by Japanese Society of Internal Medicine in Internal Medicine
- Vol. 59 (10), 1291-1294
- https://doi.org/10.2169/internalmedicine.3542-19
Abstract
Histologic transformation has been described as an acquired mechanism of resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs). We herein report the case of a woman with stage IV lung adenocarcinoma harboring EGFR exon 19 deletions who was initially treated with EGFR-TKIs; several cytotoxic chemotherapeutic regimens were used when resistance developed. A lymph node re-biopsy revealed histologic transformation of the tumor to combined small-cell lung cancer (SCLC) and squamous cell carcinoma (SCC) with retained EGFR exon 19 deletions. Following sequential chemotherapy appropriate for transformed histology, a clinical response was achieved.Keywords
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