Manifold role of ubiquitin in Helicobacter pylori infection and gastric cancer
Open Access
- 7 April 2021
- journal article
- review article
- Published by Springer Science and Business Media LLC in Cellular and Molecular Life Sciences
- Vol. 78 (10), 4765-4783
- https://doi.org/10.1007/s00018-021-03816-8
Abstract
Infection with H. pylori induces a strong host cellular response represented by induction of a set of molecular signaling pathways, expression of proinflammatory cytokines and changes in proliferation. Chronic infection and inflammation accompanied by secretory dysfunction can result in the development of gastric metaplasia and gastric cancer. Currently, it has been determined that the regulation of many cellular processes involves ubiquitinylation of molecular effectors. The binding of ubiquitin allows the substrate to undergo a change in function, to interact within multimolecular signaling complexes and/or to be degraded. Dysregulation of the ubiquitinylation machinery contributes to several pathologies, including cancer. It is not understood in detail how H. pylori impacts the ubiquitinylation of host substrate proteins. The aim of this review is to summarize the existing literature in this field, with an emphasis on the role of E3 ubiquitin ligases in host cell homeodynamics, gastric pathophysiology and gastric cancer.Keywords
Funding Information
- the European Union Program European Regional Development Fund of the Ministry of Economy, Science and Digitalization in Saxony Anhalt (ZS/2016/04/78155)
- DFG (CRC854, project A04)
- Otto-von-Guericke-Universität Magdeburg
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