A genome-wide association study in Japanese identified one variant associated with a preference for a Japanese dietary pattern
- 6 December 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in European Journal of Clinical Nutrition
- Vol. 75 (6), 937-945
- https://doi.org/10.1038/s41430-020-00823-z
Abstract
Background/Objectives Individual eating habits may be influenced by genetic factors, in addition to environmental factors. Previous studies suggested that adherence to Japanese food patterns was associated with a decreased risk of all-cause and cardiovascular disease mortality. We conducted a genome-wide association study (GWAS) in a Japanese population to find genetic variations that affect adherence to a Japanese food pattern. Subjects/Methods We analyzed GWAS data using 14,079 participants from the Japan Multi-Institutional Collaborative Cohort study. We made a Japanese food score based on six food groups. Association of the imputed variants with the Japanese food score was performed by linear regression analysis with adjustments for age, sex, total energy intake, alcohol intake (g/day), and principal components 1–10 omitting variants in the major histocompatibility region. Results We found one SNP in the 14q11.2 locus that was significantly associated with the Japanese food score with P values −8. Functional annotation revealed that the expression levels of two genes (BCL2L2, SLC22A17) were significantly inversely associated with this SNP. These genes are known to be related to olfaction and obesity. Conclusion We found a new SNP that was associated with the Japanese food score in a Japanese population. This SNP is inversely associated with genes link to olfaction and obesity.This publication has 38 references indexed in Scilit:
- An integrated map of genetic variation from 1,092 human genomesNature, 2012
- A linear complexity phasing method for thousands of genomesNature Methods, 2011
- Expression and analysis of two novel rat organic cation transporter homologs, SLC22A17 and SLC22A23Molecular and Cellular Biochemistry, 2011
- LocusZoom: regional visualization of genome-wide association scan resultsBioinformatics, 2010
- A Japanese diet and 19-year mortality: National Integrated Project for Prospective Observation of Non-Communicable Diseases and its Trends in the Aged, 1980British Journal of Nutrition, 2008
- Japanese Population Structure, Based on SNP Genotypes from 7003 Individuals Compared to Other Ethnic Groups: Effects on Population-Based Association StudiesAmerican Journal of Human Genetics, 2008
- A Unified Association Analysis Approach for Family and Unrelated Samples Correcting for StratificationAmerican Journal of Human Genetics, 2008
- Lipocalin-2 Is an Inflammatory Marker Closely Associated with Obesity, Insulin Resistance, and Hyperglycemia in HumansClinical Chemistry, 2007
- Principal components analysis corrects for stratification in genome-wide association studiesNature Genetics, 2006
- Population Structure and EigenanalysisPLoS Genetics, 2006