Abstract:Backgorund: Lai fruit seeds (Durio kutejensis) contain starch. In the pharmaceutical field, starch can be used as an ingredient in the formulation of tablet preparations such as fillers, binders, and disintegrants. Objective: This research is to determine the Potential of Lai Fruit Seed Starch (Durio Kutejensis) as A New Excipient in Pharmaceutical Preparations. Methods: The research process started from plant determination, sample collection, starch manufacture, and examination of specific and non-specific characteristics as well as testing the starch content of other fruit seeds. Result: The content of the extract is 12.5% water soluble, and the content of the extract is soluble in ethanol 1.5%. Based on the non-specific parameters of lai fruit seed starch, the water content was 11.4%, the ash content was 1.5%, and the acid insoluble ash content was 0.75%. The starch content test of lai fruit seeds was found to contain fructose. Conclusion: the seed starch of lai fruit has the potential to be used as an alternative to new excipients in pharmaceutical preparations.