Low serum albumin levels predict poor outcome in patients with acute ischaemic stroke or transient ischaemic attack
Open Access
- 25 February 2021
- journal article
- research article
- Published by BMJ in Stroke and Vascular Neurology
- Vol. 6 (3), 458-466
- https://doi.org/10.1136/svn-2020-000676
Abstract
Background To examine the relationship of serum albumin with poor functional outcome and mortality in patients with acute ischaemic stroke (AIS) or transient ischaemic attack (TIA), and perform a meta-analysis to summarise the association. Methods We analysed data from the Third China National Stroke Registry (CNSR-Ⅲ). Patients were divided into four groups based on serum albumin levels at admission. The outcomes included poor functional outcome (modified Rankin Scale (mRS) score of 3 to 6) and mortality at 3 months and 1 year. Multiple logistic regression models and Cox regression models were used to evaluate the association, respectively. We used a fixed-effect model to calculate the risk ratio for poor functional outcome and a random-effect model for mortality in the meta-analysis. Results A total of 13 618 patients were enrolled. During the 3-month follow-up period, compared with 40 to 44.9 g/L group, patients in Conclusions Low serum albumin levels predict poor functional outcome and mortality in patients with AIS or TIA.Keywords
Funding Information
- Beijing Municipal Science & Technology Commission (Z181100001818001)
- beijing excellent talents training program (2018000021469G234)
- Beijing Municipal Administration of Hospitals Incubating Program (PX2020021)
- National Natural Science Foundation of China (81870905)
- National Key R&D Program of China (2018YFC1312903)
This publication has 40 references indexed in Scilit:
- Serum albumin levels in ischemic stroke and its subtypes: Correlation with clinical outcomeNutrition, 2013
- Human serum albumin: From bench to bedsideMolecular Aspects of Medicine, 2012
- Serum Albumin in Ischemic Stroke Patients: The Higher the BetterCerebrovascular Diseases, 2009
- Hypoalbuminemia in acute ischemic stroke patients: frequency and correlatesEuropean Journal of Clinical Nutrition, 2007
- Serum albumin level and nosocomial pneumonia in stroke patientsEuropean Journal of Neurology, 2006
- Albumin Therapy of Transient Focal Cerebral IschemiaStroke, 2002
- Human Albumin Therapy of Acute Ischemic StrokeStroke, 2001
- Plasma albumin and platelet function: relevance to atherogenesis and thrombosisPlatelets, 1996
- Classification of subtype of acute ischemic stroke. Definitions for use in a multicenter clinical trial. TOAST. Trial of Org 10172 in Acute Stroke Treatment.Stroke, 1993
- Beneficial Effect of Carotid Endarterectomy in Symptomatic Patients with High-Grade Carotid StenosisThe New England Journal of Medicine, 1991