Ancient DNA indicates human population shifts and admixture in northern and southern China
Top Cited Papers
- 17 July 2020
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 369 (6501), 282-+
- https://doi.org/10.1126/science.aba0909
Abstract
Human genetic history in East Asia is poorly understood. To clarify population relationships, we obtained genome- wide data from 26 ancient individuals from northern and southern East Asia spanning 9500 to 300 years ago. Genetic differentiation in this region was higher in the past than the present, which reflects a major episode of admixture involving northern East Asian ancestry spreading across southern East Asia after the Neolithic, thereby transforming the genetic ancestry of southern China. Mainland southern East Asian and Taiwan Strait island samples from the Neolithic show clear connections with modern and ancient individuals with Austronesian-related ancestry, which supports an origin in southern China for proto-Austronesians. Connections among Neolithic coastal groups from Siberia and Japan to Vietnam indicate that migration and gene flow played an important role in the prehistory of coastal Asia.Funding Information
- Howard Hughes Medical Institute (55008731)
- National Natural Science Foundation of China (91731303)
- National Natural Science Foundation of China (41630102)
- National Natural Science Foundation of China (41925009)
- Chinese Academy of Sciences (XDB26000000)
- Chinese Academy of Sciences (XDA1905010)
- Chinese Academy of Sciences (QYZDB-SSW-DQC003)
This publication has 65 references indexed in Scilit:
- DNA analysis of an early modern human from Tianyuan Cave, ChinaProceedings of the National Academy of Sciences of the United States of America, 2013
- Denisova Admixture and the First Modern Human Dispersals into Southeast Asia and OceaniaAmerican Journal of Human Genetics, 2011
- Testing for Ancient Admixture between Closely Related PopulationsMolecular Biology and Evolution, 2011
- Genetic Structure of the Han Chinese Population Revealed by Genome-wide SNP VariationAmerican Journal of Human Genetics, 2009
- Fast model-based estimation of ancestry in unrelated individualsGenome Research, 2009
- Fast and accurate short read alignment with Burrows–Wheeler transformBioinformatics, 2009
- Patterns of damage in genomic DNA sequences from a NeandertalProceedings of the National Academy of Sciences of the United States of America, 2007
- Measurement of the human allele frequency spectrum demonstrates greater genetic drift in East Asians than in EuropeansNature Genetics, 2007
- PLINK: A Tool Set for Whole-Genome Association and Population-Based Linkage AnalysesAmerican Journal of Human Genetics, 2007
- Genetic studies of human diversity in East AsiaPhilosophical Transactions B, 2007