Kleeb Bua Daeng, a Thai Traditional Herbal Formula, Ameliorated Unpredictable Chronic Mild Stress-Induced Cognitive Impairment in ICR Mice
Open Access
- 14 December 2019
- Vol. 24 (24), 4587
- https://doi.org/10.3390/molecules24244587
Abstract
Thai traditional herbal formula ‘’Kleeb Bua Daeng (KBD)’’consists of a 1:1:1 ratio (dry weight) of three medicinal plants: Piper nigrum fruit, the aerial part of Centella asiatica and the petals of Nelumbo nucifera. Oral administration of KBD to unpredictable chronic mild stress (UCMS) mice significantly improved their cognitive function caused by chronic mild stress. Daily administration of KBD significantly decreased the serum corticosterone (CORT) and malondialdehyde (MDA) levels but increased the catalase and superoxide dismutase activities in both frontal cortex and hippocampus. The effects of KBD were similar to those caused by oral administration of vitamin E. HPLC analysis of the KBD extract revealed the presence of piperine, madecassoside, asiaticoside, luteolin-7-O-glucoside, rutin, kaempferol-3-glucoside, quercetin, kaempferol and ferulic acid as major constituents.This publication has 55 references indexed in Scilit:
- Oxidative stress in health and disease: The therapeutic potential of Nrf2 activationMolecular Aspects of Medicine, 2011
- Effects of Nelumbo nucifera Rhizome Extract on Cell Proliferation and Neuroblast Differentiation in the Hippocampal Dentate Gyrus in a Scopolamine‐induced Amnesia Animal ModelPhytotherapy Research, 2010
- Chemical and molecular mechanisms of antioxidants: experimental approaches and model systemsJournal of Cellular and Molecular Medicine, 2010
- Glucocorticoid Generates ROS to Induce Oxidative Injury in the Hippocampus, Leading to Impairment of Cognitive Function of RatsJournal of Clinical Biochemistry and Nutrition, 2010
- Free radicals, antioxidants and functional foods: Impact on human healthPharmacognosy Reviews, 2010
- Mechanism of glucocorticoid-induced oxidative stress in rat hippocampal slice culturesCanadian Journal of Physiology and Pharmacology, 2009
- Modulation ofin vivooxidative status by exogenous corticosterone and restraint stress in ratsStress, 2009
- Novel effects of Nelumbo nucifera rhizome extract on memory and neurogenesis in the dentate gyrus of the rat hippocampusNeuroscience Letters, 2008
- Chronic stress impairs rat spatial memory on the Y maze, and this effect is blocked by tianeptine treatment.Behavioral Neuroscience, 1996
- Chronic stress impairs rat spatial memory on the Y maze, and this effect is blocked by tianeptine treatment.Behavioral Neuroscience, 1996