High-phytate/low-calcium diet is a risk factor for crystal nephropathies, renal phosphate wasting, and bone loss
Open Access
- 9 April 2020
- journal article
- research article
- Published by eLife Sciences Publications, Ltd in eLife
Abstract
Phosphate overload contributes to mineral bone disorders that are associated with crystal nephropathies. Phytate, the major form of phosphorus in plant seeds, is known as an indigestible and of negligible nutritional value in humans. However, the mechanism and adverse effects of high-phytate intake on Ca2+ and phosphate absorption and homeostasis are unknown. Here, we show that excessive intake of phytate along with a low-Ca2+ diet fed to rats contributed to the development of crystal nephropathies, renal phosphate wasting, and bone loss through tubular dysfunction secondary to dysregulation of intestinal calcium and phosphate absorption. Moreover, Ca2+ supplementation alleviated the detrimental effects of excess dietary phytate on bone and kidney through excretion of undigested Ca2+-phytate, which prevented a vicious cycle of intestinal phosphate overload and renal phosphate wasting while improving intestinal Ca2+ bioavailability. Thus, we demonstrate that phytate is digestible without a high-Ca2+ diet and is a risk factor for phosphate overloading and for the development of crystal nephropathies and bone disease.Funding Information
- National Research Foundation of Korea (2017R1D1A1B03031094)
- National Research Foundation of Korea (2019R1A2C2008130)
- Ministry of Food and Drug Safety (14182MFDS460)
- Korea Health Industry Development Institute (HI14C1135)
- Ministry of Food and Drug Safety (16181MFDS381)
This publication has 59 references indexed in Scilit:
- Early Skeletal and Biochemical Alterations in Pediatric Chronic Kidney DiseaseClinical Journal of the American Society of Nephrology, 2012
- Vegetarian Compared with Meat Dietary Protein Source and Phosphorus Homeostasis in Chronic Kidney DiseaseClinical Journal of the American Society of Nephrology, 2011
- The FGF23–Klotho axis: endocrine regulation of phosphate homeostasisNature Reviews Endocrinology, 2009
- Do mammals make all their own inositol hexakisphosphate?Biochemical Journal, 2008
- NHERF1Mutations and Responsiveness of Renal Parathyroid HormoneThe New England Journal of Medicine, 2008
- The concentrations of iron, calcium, zinc and phytate in cereals and legumes habitually consumed by infants living in East Lombok, IndonesiaJournal of Food Composition and Analysis, 2007
- Avian multiple inositol polyphosphate phosphatase is an active phytase that can be engineered to help ameliorate the planet's “phosphate crisis”Journal of Biotechnology, 2006
- Effect of Dietary Level of Phytic Acid on Hepatic and Serum Lipid Status in Rats Fed a High-sucrose DietBioscience, Biotechnology, and Biochemistry, 2004
- A new mechanism for induced vitamin D deficiency in calcium deprivationNature, 1987
- Renal toxicity of phosphate in ratsKidney International, 1980