Saurobacciosides A - C: three new glycosides fromSauropus bacciformiswith their cytotoxic activity
- 26 February 2021
- journal article
- research article
- Published by Taylor & Francis Ltd in Natural Product Research
- Vol. 36 (6), 1476-1484
- https://doi.org/10.1080/14786419.2021.1892670
Abstract
Three new glycosides, named as saurobaccioside A (1), saurobaccioside B (2), saurobaccioside C (3), together with five known magastigmanes, canangaionoside (4), (6S,9S)-roseoside (5), cucumegastigmane I (6), icariside B5 (7), linarionoside A (8) were isolated from the whole plant of Sauropus bacciformis (L.) Airy Shaw. Their structures were established by extensive spectroscopic analysis (UV, IR, HR-ESI-MS and NMR) and by comparison of the spectral data with those reported in the literature. The absolute configurations of compounds 2 and 3 were elucidated by experimental CD spectra. Compounds 1-8 were screened their cytotoxic activities towards CAL27 and MDAMB231 cancer cell lines. Compound 1 exhibited significant cytotoxic activity towards CAL27 and MDAMB231 cell lines with IC50 values of 3.21 ± 0.23 and 4.75 ± 0.17 µM, respectively, which were smaller than those of positive control capecitabine (IC50: 8.20 ± 0.75 and 5.20 ± 0.89 µM). Other compounds (2-8) were inactive. GRAPHICAL ABSTRACTKeywords
Funding Information
- Vietnam National Foundation for Science and Technology Development (104.01-2019.18)
This publication has 11 references indexed in Scilit:
- Anti-viral and cytotoxic norbisabolane sesquiterpenoid glycosides from Phyllanthus emblica and their absolute configurationsPhytochemistry, 2015
- Megastigmane glucosides and an unusual monoterpene from the leaves of Cananga odorata var. odorata, and absolute structures of megastigmane glucosides isolated from C. odorata var. odorata and Breynia officinalisJournal of Natural Medicines, 2010
- Reinvestigation of the Absolute Stereochemistry of Megastigmane Glucoside, Icariside B5CHEMICAL & PHARMACEUTICAL BULLETIN, 2010
- Two New Megastigmanes from the Leaves of Cucumis sativusCHEMICAL & PHARMACEUTICAL BULLETIN, 2007
- Synthesis of Optically Active Vomifoliol and Roseoside StereoisomersCHEMICAL & PHARMACEUTICAL BULLETIN, 2005
- Antiproliferative Activity of the Main Constituents from Phyllanthus emblicaBiological & Pharmaceutical Bulletin, 2004
- Revision of the Malesian and Thai species of Sauropus (Euphorbiaceae: Phyllanthoideae)Blumea - Biodiversity, Evolution and Biogeography of Plants, 2003
- Lignan and megastigmane glycosides from Sauropus androgynusPhytochemistry, 2003
- Novel Norsesquiterpenoids from the Roots of Phyllanthus emblicaJournal of Natural Products, 2000
- Linarionosides A–C and acyclic monoterpene diglucosides from Linaria japonicaPhytochemistry, 1994