Enantioselective Reductive Coupling of Imines Templated by Chiral Diboron
- 10 June 2020
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of the American Chemical Society
- Vol. 142 (23), 10337-10342
- https://doi.org/10.1021/jacs.0c04558
Abstract
We herein report a general, practical, and highly efficient method for asymmetric synthesis of a wide range of chiral vicinal diamines via reductive coupling of imines templated by chiral diboron. The protocol features high enantioselectivity and stereospecificity, mild reaction conditions, simple operating procedures, use of readily available starting materials, and a broad substrate scope. The method signifies the generality of diboron-enabled [3,3]-sigmatropic rearrangement.Funding Information
- K. C. Wong Education Foundation
- Science and Technology Commission of Shanghai Municipality (18520712200)
- National Natural Science Foundation of China (21432007, 21572246, 21702223, 21725205)
- Chinese Academy of Sciences (QYZDY-SSW-SLH029, XDB20000000)
- Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences
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