A Severe Episode of Hemolytic Anemia After Amoxicillin Exposure in A G6PD Deficient Patient
Open Access
- 1 January 2019
- journal article
- Published by Fortune Journals in Archives of Clinical and Medical Case Reports
- Vol. 03 (03), 104-112
- https://doi.org/10.26502/acmcr.96550068
Abstract
Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzyme deficiency worldwide, with genetic variants resulting in a range of phenotypes that vary from asymptomatic to severe hemolysis. The G6PD deficiency A- variant is associated with hemolysis., typically due to infectious or medication exposures, particularly antimalarials and sulfonamide drugs. We report a case of severe hemolytic anemia in a G6PD deficient patient whose only known exposure was amoxicillin two weeks prior to his episode of severe hemolysis, for which he presented to our hospital. An extensive infectious and hematologic workup resulted negative, with the exception of a positive G6PD deficiency result. Although rare, we suggest that the patient’s severe hemolytic anemia is probably related to amoxicillin exposure.Keywords
This publication has 16 references indexed in Scilit:
- Amoxicillin/Clavulanic Acid-Induced ThrombocytopeniaHospital Pharmacy, 2014
- Bactericidal Antibiotics Induce Mitochondrial Dysfunction and Oxidative Damage in Mammalian CellsScience Translational Medicine, 2013
- Understanding the mechanisms for metabolism-linked hemolytic toxicity of primaquine against glucose 6-phosphate dehydrogenase deficient human erythrocytes: Evaluation of eryptotic pathwayToxicology, 2012
- Amoxicillin-Induced Hemolytic Anemia in a Child with Glucose 6-Phosphate Isomerase DeficiencyAnnals of Pharmacotherapy, 2010
- The global prevalence of glucose-6-phosphate dehydrogenase deficiency: A systematic review and meta-analysisBlood Cells, Molecules, and Diseases, 2009
- Glucose‐6‐phosphate dehydrogenase laboratory assay: How, when, and why?IUBMB Life, 2008
- Acute Liver Failure Due To Amoxicillin and Amoxicillin/ClavulanateDigestive Diseases and Sciences, 2005
- CYTOMEGALOVIRUS INFECTION AND APLASTIC CRISIS IN GLUCOSE-6-PHOSPHATE DEHYDROGENASE DEFICIENCYThe Lancet, 1987
- Amoxycillin induced pancytopenia.BMJ, 1985
- Amoxicillin-Induced Immune HemolysisActa Haematologica, 1985