Identification of metabolic syndrome using phenotypes consisting of triglyceride levels with anthropometric indices in Korean adults
Open Access
- 27 February 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in BMC Endocrine Disorders
- Vol. 20 (1), 1-12
- https://doi.org/10.1186/s12902-020-0510-0
Abstract
Background The metabolic syndrome (MetS) has shown strong associations with the hypertriglyceridemic waist (HW) phenotype. The best anthropometric indicator of MetS remains controversial. Furthermore, no studies have investigated alternative indices that could replace waist circumference in the HW phenotype. The objectives of this study were to find the best indicator of MetS among anthropometric indices and to examine the predictive power of phenotypes consisting of triglyceride levels with anthropometric indices. Methods A total of 12,025 subjects participated in this retrospective cross-sectional study. All subjects were recruited between November 2016 and August 2007 from hospitals in 28 urban and rural regions in South Korea. The data analyzed in this study were obtained from the Korean Health and Genome Epidemiology Study database and the Korea Institute of Oriental Medicine. Results The proportion of patients with MetS ranged from 9 to 57% according to age and gender groups. Waist circumference (WC) was best indicator of MetS in men of all age groups. However, in women aged 40–49 years, the waist-to-height ratio (WHtR) was the best indicator of MetS. Rib circumference and chest circumference were the strongest indicators in women aged 50–59 years and 70–79 years, respectively. The combination of WC and triglyceride (TG) was the best indicator of MetS in men and women overall. However, interestingly, the best indicator was TG + WHtR in women aged 40–49 years and TG + forehead-to-waist ratio in women aged 70–79 years. Conclusions The best indicator of MetS in terms of individual anthropometric indices and the various phenotypes combining a single anthropometric index with TG may differ subtly according to age group in women, but not in men. Our findings provide insight into a simple and inexpensive method that could be used to identify MetS in initial health screening efforts in epidemiology and public health.Keywords
Funding Information
- National Research Foundation of Korea (NRF-2015M3A9B6027139)
This publication has 46 references indexed in Scilit:
- Hypertriglyceridemic Waist Might Be an Alternative to Metabolic Syndrome for Predicting Future Diabetes MellitusPLOS ONE, 2013
- Predictors of Metabolic Syndrome in the Iranian Population: Waist Circumference, Body Mass Index, or Waist to Hip Ratio?Cholesterol, 2013
- Obesity Index That Better Predict Metabolic Syndrome: Body Mass Index, Waist Circumference, Waist Hip Ratio, or Waist Height RatioJournal of Obesity, 2013
- Hypertriglyceridemia and Waist Circumference Predict Cardiovascular Risk among HIV Patients: A Cross-Sectional StudyPLOS ONE, 2011
- Waist-to-Height: Cutoff Matters in Predicting Metabolic Syndrome in Mexican ChildrenMetabolic Syndrome and Related Disorders, 2011
- The WEKA data mining softwareACM SIGKDD Explorations Newsletter, 2009
- Waist circumference, body mass index and waist to hip ratio for prediction of the metabolic syndrome in ChineseNutrition, Metabolism and Cardiovascular Diseases, 2009
- Waist-to-Height Ratio Is a Highly Sensitive Index for the Metabolic Syndrome in a Mediterranean PopulationMetabolic Syndrome and Related Disorders, 2009
- Metabolic syndrome in Japanese men and women with special reference to the anthropometric criteria for the assessment of obesity: Proposal to use the waist-to-height ratioPreventive Medicine, 2006
- Diagnosis and Management of the Metabolic SyndromeCirculation, 2005