RhIII-Catalyzed Direct Heteroarylation of C(sp3)–H and C(sp2)–H Bonds in Heterocycles with N-Heteroaromatic Boronates
- 2 September 2021
- journal article
- research article
- Published by American Chemical Society (ACS) in Organic Letters
- Vol. 23 (18), 7177-7182
- https://doi.org/10.1021/acs.orglett.1c02546
Abstract
Herein, we disclose a RhIII-catalyzed heteroarylation of C(sp3)–H and C(sp2)–H bonds in heterocycles with organoboron reagents. This protocol displays high efficiency and excellent functional group tolerance. A range of heterocyclic boronates with strong coordinating atoms, including pyridine, pyrimidine, pyrazole, thiophene, and furan derivatives, can be extensively served as the coupling reagents. The direct heteroarylation method could supply potential application in terms of the synthesis of drug molecules with multiple heterocycles.Keywords
Funding Information
- Liaocheng University (318051726)
- National Natural Science Foundation of China (21801108)
- Natural Science Foundation of Shandong Province (ZR2019PB001)
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