Albumin-mediated alteration of plasma zinc speciation by fatty acids modulates blood clotting in type-2 diabetes
Open Access
- 1 February 2021
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Science
- Vol. 12 (11), 4079-4093
- https://doi.org/10.1039/d0sc06605b
Abstract
Zn2+ is an essential regulator of coagulation. In plasma, Zn2+ availability is fine-tuned by human serum albumin (HSA). Here we show that elevated fatty acid levels contribute to altered coagulation in type-2 diabetes through Zn2+ mishandling by HSA.Funding Information
- British Heart Foundation (FS/15/42/31556, PG/15/9/31270)
- Commonwealth Scholarship Commission (MWCN-2017-294)
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