Efficacy and safety of aliskiren combination therapy: a protocol for an umbrella review
Open Access
- 1 January 2021
- Vol. 11 (3), e043807
- https://doi.org/10.1136/bmjopen-2020-043807
Abstract
Introduction Efficacy of aliskiren combination therapy with other antihypertensive has been evaluated in the treatment of patients with hypertension in recent systematic reviews. However, most previous reviews only focused on one single health outcome or one setting, none of them made a full summary that assessed the impact of aliskiren combination treatment comprehensively. As such, this umbrella review based on systematic reviews and meta-analyses is aimed to synthesise the evidences on efficacy, safety and tolerability of aliskiren-based therapy for hypertension and related comorbid patients. Methods and analysis A comprehensive search of PubMed, EMBASE, Cochrane Library, CNKI published from inception to August 2020 will be conducted. The selected articles are systematic reviews which evaluated efficacy, safety and tolerability of aliskiren combination therapy. Two reviewers will screen eligible articles, extract data and evaluate quality independently. Any disputes will be resolved by discussion or the arbitration of a third person. The quality of reporting evidence will be assessed using the Assessment of Multiple Systematic Reviews V.2 tool tool. We will take a mixed-methods approach to synthesising the review literatures, reporting summary of findings tables and iteratively mapping the results. Ethics and dissemination Ethical approval is not required for the study, as we would only collect data from available published materials. This umbrella review will be also submitted to a peer-reviewed journal for publication after completion. PROSPERO registration number CRD42020192131.This publication has 20 references indexed in Scilit:
- Next-generation systematic reviews: prospective meta-analysis, individual-level data, networks and umbrella reviewsBritish Journal of Sports Medicine, 2017
- Summarizing systematic reviewsJBI Evidence Implementation, 2015
- Effect of aliskiren on cardiovascular outcomes in patients with prehypertension: a meta-analysis of randomized controlled trialsDrug Design, Development and Therapy, 2015
- Ycasd– a tool for capturing and scaling data from graphical representationsBMC Bioinformatics, 2014
- Systematic review finds overlapping reviews were not mentioned in every other overviewJournal of Clinical Epidemiology, 2014
- Aliskiren/Amlodipine vs. Aliskiren/Hydrochlorothiazide in Hypertension: Indirect Meta-Analysis of Trials Comparing the Two Combinations vs. MonotherapyAmerican Journal of Hypertension, 2013
- Aliskiren and Amlodipine in the Management of Essential Hypertension: Meta-Analysis of Randomized Controlled TrialsPLOS ONE, 2013
- AliskirenDrugs, 2010
- Long-term safety, tolerability and efficacy of combination therapy with aliskiren and amlodipine in patients with hypertensionCurrent Medical Research and Opinion, 2009
- Efficacy and safety of combined use of aliskiren and valsartan in patients with hypertension: a randomised, double-blind trialThe Lancet, 2007