Integrity of the uncinate fasciculus is associated with the onset of bipolar disorder: a 6-year followed-up study
Open Access
- 5 February 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Translational Psychiatry
- Vol. 11 (1), 1-7
- https://doi.org/10.1038/s41398-021-01222-z
Abstract
Patients with Bipolar Disorder (BD) are associated with aberrant uncinate fasciculus (UF) that connects amygdala-ventral prefrontal cortex (vPFC) system, but the casual relationship is still uncertain. The research aimed to investigate the integrity of UF among offspring of patients with BD and investigate its potential causal association with subsequent declaration of BD. The fractional anisotropy (FA) and mean diffusivity (MD) of UF were compared in asymptomatic offspring (AO, n = 46) and symptomatic offspring (SO, n = 45) with a parent with BD, and age-matched healthy controls (HCs, n = 35). Logistic regressions were performed to assess the predictive effect of UF integrity on the onset of BD. The three groups did not differ at baseline in terms of FA and MD of the UF. Nine out of 45 SO developed BD over a follow-up period of 6 years, and the right UF FA predicted the onset of BD (p = 0.038, OR = 0.212, 95% CI = 0.049–0.917). The ROC curve revealed that the right UF FA predicted BD onset (area-under-curve = 0.859) with sensitivity of 88.9% and specificity of 77.3%. The complementary whole-brain tract-based spatial statistics (TBSS) showed that widespread increases of FA were found in the SO group compared with HCs, but were not associated with the onset of BD. Our data provide evidence supporting the causal relationship between the white matter structural integrity of the amygdala-vPFC system and the onset of BD in genetically at-risk offspring of BD patients.Funding Information
- National Natural Science Foundation of China (81671347, 81671347, 81671347, 81671347, 81671347, 81671347, 81671347, 81671347, 81671347, 81671347)
This publication has 49 references indexed in Scilit:
- Neuroimaging Markers of Risk, Disease Expression, and Resilience to Bipolar DisorderCurrent Psychiatry Reports, 2019
- Clinical staging model in offspring of parents with bipolar disorder: a systematic reviewBipolar Disorders, 2018
- Resting-state fMRI signals in offspring of parents with bipolar disorder at the high-risk and ultra-high-risk stages and their relations with cognitive functionJournal of Psychiatric Research, 2018
- Structural connections support emotional connections: Uncinate Fasciculus microstructure is related to the ability to decode facial emotion expressionsNeuropsychologia, 2017
- Bipolar disorderThe Lancet, 2015
- All the world’s a (clinical) stage: rethinking bipolar disorder from a longitudinal perspectiveMolecular Psychiatry, 2014
- A hitchhiker's guide to diffusion tensor imagingFrontiers in Neuroscience, 2013
- Functional neuroanatomy of bipolar disorder: structure, function, and connectivity in an amygdala–anterior paralimbic neural systemBipolar Disorders, 2012
- Diffusion Tensor Imaging Study of White Matter Fiber Tracts in Pediatric Bipolar Disorder and Attention-Deficit/Hyperactivity DisorderBiological Psychiatry, 2009
- The Heritability of Bipolar Affective Disorder and the Genetic Relationship to Unipolar DepressionArchives of General Psychiatry, 2003