Design study of fully wearable high-performance brain PETs for neuroimaging in free movement

Abstract

A practical wearable brain PET scanner capable of dynamic neuroimaging during free bodily movement will enable potential breakthrough basic neuroscience studies and help develop imaging-based neurological diagnoses and treatments. Weight, brain coverage, and sensitivity are three fundamental technical obstacles in the development of Fully Wearable High-Performance (FWHP) brain PET scanners. The purpose of this study is to investigate the feasibility of building a FWHP brain PET using a limited volume of lutetium-yttrium oxyorthosilicate (LYSO) scintillator crystals. Six scanners, consisted of the same volume (2.66 kg) of LYSO scintillators with combinations of 2 different crystal pitches (3 mm and 1.5 mm) and 3 different crystal lengths (20 mm, 10 mm, and 5 mm), were simulated. The performances of the six scanners were assessed and compared with Siemen's HRRT brain PET and mCT whole-body PET, in terms of aperture, axial field of views (AFOV), sensitivity, spatial resolution, count rates, and image noise property. The time-of-flight (TOF) information was included in the image reconstruction to improve the effective sensitivity. The effects of the TOF was assessed by scanning a Jaszczak phantom and reconstructing images with the maximum likelihood expectation maximization (MLEM) algorithm with different timing settings (non-TOF, 500 ps, 200 ps, 100 ps and 50 ps Coincidence Time Resolution, CTR). The signal-noise ratio (SNR) of the images were assessed and compared with those of the HRRT scanner and mCT scanner. The results show that it is possible to construct a FWHP brain PET with better spatial resolution than the dedicated HRRT brain PET, comparable effective sensitivity (with 50 similar to 100 ps CTR), and whole-brain coverage (23.7 cm inner diameter and 13.4 cm axial field of view) using 2.66 kg of LYSO.