Long-term effect of YAG laser iridotomy on corneal endothelium in primary angle closure suspects: a 72-month randomised controlled study
- 19 May 2020
- journal article
- research article
- Published by BMJ in British Journal of Ophthalmology
- Vol. 105 (3), 348-353
- https://doi.org/10.1136/bjophthalmol-2020-315811
Abstract
Purposes To evaluate the effect of YAG laser peripheral iridotomy (LPI) on corneal endothelial cell density (ECD) and morphology in primary angle closure suspects (PACS) over 72 months. Methods The Zhongshan Angle Closure Prevention Trial is a single-centre randomised controlled trial. Subjects with bilateral PACS received YAG LPI prophylactic treatment in one eye randomly, while the fellow eye served as control. Central corneal ECD and morphology were assessed using non-contact specular microscopy (SP-2000P, Topcon) at baseline, 6, 18, 36, 54 and 72 months postoperatively. Mixed model analysis was conducted to compare the difference between treated and fellow eyes. Results A total of 875 participants were included, with a mean age of 59.3±5.0 years and 83.5% female. The ECD declined significantly (pConclusion ECD decreases over time primarily due to ageing effect. YAG LPI does not appear to cause clinically significant corneal endothelial damage over 72 months after treatment. Trial registration number ISRCTN45213099.Keywords
Funding Information
- Special Trustees of Moorfields Eye Hospital
- National Natural Science Foundation of China (81420108008)
- British Council for Prevention of Blindness
- National Institute for Health Research (NIHR) Biomedical Research Centre (NIHR-BRC2 009; Moorfields/UCL-IOO)
- Fight for Sight UK (No.1655)
- Sun Yat-Sen University 5010 Project Fund (No.2007033)
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