Low-Power Near-Infrared-Responsive Upconversion Nanovectors
- 1 February 2021
- journal article
- research article
- Published by American Chemical Society (ACS) in ACS Applied Materials & Interfaces
- Vol. 13 (6), 7094-7101
- https://doi.org/10.1021/acsami.0c21115
Abstract
Activating upconversion nanoparticle-based photoresponsive nanovectors (UCPNVs) by upconversion visible light at low-power near-infrared (NIR) excitation can realize deeper biotissue stimulation with a minimized overheating effect and photodamage. Here, we demonstrate a facile strategy to construct new surface-decorated UCPNVs based on Passerini three-component reaction (P-3CR) in highly convenient and effective manners. Such UCPNVs materials have a tailored deprotecting wavelength that overlaps upconversion blue light. By using 3-perylenecarboxaldehyde, Tm3+/Yb3+ ion-doped UCNP-containing isocyanides, and antitumor agent chlorambucil as the three components, the resulting monodisperse UCPNV exhibits an efficient release of caged chlorambucil under a very low 976 nm power. This approach expands the synthetic toolbox to enable quick development of UCPNVs for UCNP-assisted low-power NIR photochemistry.Funding Information
- Ministry of Education of the People's Republic of China (GK201902003, YJ201940)
- Fonds de Recherche du Qu?bec - Nature et Technologies
- Natural Sciences and Engineering Research Council of Canada
- National Natural Science Foundation of China (11804214, 21905182)
- State Key Laboratory of Integrated Optoelectronics, Jilin University (IOSKL2018KF06)
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