Intragastric Botulinum Toxin A Injection Is an Effective Obesity Therapy for Patients with BMI > 40 kg/m2: a Systematic Review and Meta-analysis
- 31 July 2020
- journal article
- review article
- Published by Springer Science and Business Media LLC in Obesity Surgery
- Vol. 30 (10), 4081-4090
- https://doi.org/10.1007/s11695-020-04842-4
Abstract
We conducted a systematic review and meta-analysis to assess the efficacy of intragastric BTA injection in patients with obesity and morbid obesity. Five RCTs were identified. Intragastric BTA injection was no superior to saline in absolute weight loss or BMI change, but significantly lengthened the gastric emptying time (MD, 15.57; 95% CI, 8.75 to 22.38). In meta-regression analysis, the absolute weight loss was lower in the patients with high baseline BMI. In subgroup analysis, the use of BTA in absolute weight loss was significantly lower among the patients with baseline BMI more than 40 kg/m2 (MD, − 5.31; 95% CI, − 6.17 to − 4.45). The benefit of intragastric BTA injection in reduction of absolute weight was observed in patients with baseline BMI more than 40 kg/m2.Keywords
This publication has 45 references indexed in Scilit:
- The Role of Statins in Prevention and Treatment of Community Acquired Pneumonia: A Systematic Review and Meta-AnalysisPLOS ONE, 2013
- Benefit-risk paradigm for clinical trial design of obesity devices: FDA proposalSurgical Endoscopy, 2012
- Analysis of pacemaker activity in the human stomachJournal Of Physiology-London, 2011
- Intragastric injection of botulinum toxin for the treatment of obesity. Where are we?World Journal of Gastroenterology, 2008
- Treatment of morbid obesity by intraparietogastric administration of botulinum toxin: a randomized, double-blind, controlled studyInternational Journal of Obesity, 2006
- Effect of botulinum toxin antral injection on gastric emptying and weight reduction in obese patients: a pilot studyAlimentary Pharmacology & Therapeutics, 2006
- Measuring inconsistency in meta-analysesBMJ, 2003
- Advanced methods in meta‐analysis: multivariate approach and meta‐regressionStatistics in Medicine, 2002
- Botulinum toxin injected in the gastric wall reduces body weight and food intake in ratsAlimentary Pharmacology & Therapeutics, 2000
- A random‐effects regression model for meta‐analysisStatistics in Medicine, 1995