Dual-targeted and MRI-guided photothermal therapyviairon-based nanoparticles-incorporated neutrophils
- 19 February 2021
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Biomaterials Science
- Vol. 9 (11), 3968-3978
- https://doi.org/10.1039/d1bm00127b
Abstract
Nanoparticle-mediated photothermal therapy (PTT) has shown promising capability for tumor therapy through the high local temperature at the tumor site generated by a photothermal agent (PTA) under visible or near-infrared (NIR) irradiation. Improving the accumulation of PTA at the tumor site is crucial to achieving effective photothermal treatment. Here, we developed temperature-activatable engineered neutrophils (Ne) by combining indocyanine green (ICG)-loaded magnetic silica NIR-sensitive nanoparticles (NSNP), which provide the potential for dual-targeted photothermal therapy. The combined effect of neutrophil targeting and magnetic targeting increased the accumulation of PTA at the tumor site. According to magnetic resonance imaging (MRI), the retention of intravenous injected NSNP-incorporated neutrophils within the tumor site was markedly augmented as compared to free NSNP. Furthermore, when irradiated by NIR, NSNP could cause a high local temperature at the tumor site and the thermal stimulation of neutrophils. The heat can kill tumor cells directly, and also lead to the death of neutrophils, upon which active substances with tumor-killing efficacy will be released to kill residual tumor cells and thus reduce tumor recurrence. Thereby, our therapy achieved the elimination of malignancy in the mouse model of the pancreatic tumor without recurrence. Given that all materials used in this system have been approved for use in humans, the transition of this treatment method to clinical application is plausible.Keywords
Funding Information
- Natural Science Foundation of Jiangxi Province (20202BAB216044)
- Fundamental Research Funds for the Central Universities (22120200013)
- Natural Science Foundation of Jiangsu Province (BK20180551)
- National Natural Science Foundation of China (81772285, 82001953, 82002843)
This publication has 47 references indexed in Scilit:
- Elevating body temperature enhances hematopoiesis and neutrophil recovery after total body irradiation in an IL-1–, IL-17–, and G-CSF–dependent mannerBlood, 2012
- Febrile-Range Hyperthermia Modifies Endothelial and Neutrophilic Functions to Promote ExtravasationAmerican Journal of Respiratory Cell and Molecular Biology, 2012
- Neutrophil Function: From Mechanisms to DiseaseAnnual Review of Immunology, 2012
- Novel innate cancer killing activity in humansCancer Cell International, 2011
- Heat Shock Co-Activates Interleukin-8 TranscriptionAmerican Journal of Respiratory Cell and Molecular Biology, 2008
- Alternating electric fields arrest cell proliferation in animal tumor models and human brain tumorsProceedings of the National Academy of Sciences of the United States of America, 2007
- Epithelial NEMO links innate immunity to chronic intestinal inflammationNature, 2007
- Synthesis of Magnetic Microspheres with Immobilized Metal Ions for Enrichment and Direct Determination of Phosphopeptides by Matrix‐Assisted Laser Desorption Ionization Mass SpectrometryAdvanced Materials, 2006
- Mouse bone marrow contains large numbers of functionally competent neutrophilsJournal of Leukocyte Biology, 2003
- Granulocyte-colony stimulating factor enhances anti-tumour effect of hyperthermiaInternational Journal of Hyperthermia, 2000