JMJD6 Is a Druggable Oxygenase That Regulates AR-V7 Expression in Prostate Cancer
Open Access
- 15 February 2021
- journal article
- research article
- Published by American Association for Cancer Research (AACR) in Cancer Research
- Vol. 81 (4), 1087-1100
- https://doi.org/10.1158/0008-5472.can-20-1807
Abstract
This study identifies JMJD6 as being critical for the generation of AR-V7 in prostate cancer, where it may serve as a tractable target for therapeutic intervention.Keywords
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Funding Information
- cDNA (pcDNA3-JMJD6-WT, pcDNA3-JMJD6-ASM2, pcDNA3-JMJD6-BM1)
- Cancer Research UK (RIA17-ST2-014)
- European Research Council (683136)
- Swiss Cancer (4267)
- Swiss National Science Foundation (176045)
- Prostate Cancer Foundation (19CHAL08)
- Italian Association for Cancer Research (22030)
- CRUK (C8717/A18245)
- Wellcome Trust (106244/Z/14/Z)
- DOD (W81XWH-17-0323, W81XWH-20-0146, W81XWH-17-0414)
- Prostate Cancer UK (CEO13_2-002)
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