Why it might be bad for brain cells to eat malaria parasites
Open Access
- 2 February 2021
- journal article
- editorial
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 218 (3)
- https://doi.org/10.1084/jem.20202664
Abstract
In this issue, Adams et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20201266) show that red blood cells infected with strains of Plasmodium falciparum, which are commonly found in cerebral malaria patients, are specifically internalized by brain endothelial cells, perhaps contributing to the symptoms of the disease.This publication has 14 references indexed in Scilit:
- Variant surface antigens of Plasmodium falciparum and their roles in severe malariaNature Reviews Microbiology, 2017
- Structure-Guided Identification of a Family of Dual Receptor-Binding PfEMP1 that Is Associated with Cerebral MalariaCell Host & Microbe, 2017
- Interaction between Endothelial Protein C Receptor and Intercellular Adhesion Molecule 1 to Mediate Binding of Plasmodium falciparum-Infected Erythrocytes to Endothelial CellsmBio, 2016
- Severe adult malaria is associated with specific PfEMP1 adhesion types and high parasite biomassProceedings of the National Academy of Sciences of the United States of America, 2016
- Brain Swelling and Death in Children with Cerebral MalariaThe New England Journal of Medicine, 2015
- Structural Conservation Despite Huge Sequence Diversity Allows EPCR Binding by the PfEMP1 Family Implicated in Severe Childhood MalariaCell Host & Microbe, 2015
- Loss of endothelial protein C receptors links coagulation and inflammation to parasite sequestration in cerebral malaria in African childrenBlood, 2013
- Severe malaria is associated with parasite binding to endothelial protein C receptorNature, 2013
- Lethal Malaria: Marchiafava and Bignami Were RightThe Journal of Infectious Diseases, 2013
- Intracranial pressure in African children with cerebral malariaThe Lancet, 1991