Clinical Therapy of Shujin Huoxue Tablet Combined with Sodium Hyaluronate on Inflammatory Factors of Synovial Fluid (IL-6, TNF-α) in the Treatment of Knee Osteoarthritis: Clinical Trial Study
Open Access
- 29 June 2021
- journal article
- research article
- Published by ResearchersLinks Ltd in Pakistan Journal of Zoology
- Vol. 53 (5), 1723-1728
- https://doi.org/10.17582/journal.pjz/20200418160406
Abstract
Sodium hyaluronate are used to reduce pain and improve function in patients with knee osteoarthritis (KOA) and in traditional Chinese medicine, Shujin Huoxue Tablets (SJHXT) is known to be a useful medicine for KOA. The aim of this study was to investigate the effects of SJHXT combined with sodium hyaluronate on synovial inflammation in a patients with KOA. A total of 180 patients with knee osteoarthritis who were treated in our hospital were enrolled as the study subjects who were divided into study group and reference group, each with 90 cases. The reference group received sodium hyaluronate injection treatment, while the study group was given SJHXT combined with sodium hyaluronate. The therapeutic effects were compared between the two groups. Comparison of Lysholm knee score scale, WOMAC score, and joint VAS score between the two groups showed that the study group had a significant advantage over the reference group after treatment, p<0.05. Comparison of synovial fluid inflammatory factors before and after treatment between the two groups indicated more obvious improvement in the study group than in the reference group, p<0.05. Comparison of overall treatment efficiency of the two groups showed significantly higher efficiency in the study group than in the reference group, p<0.05. To conclude SJHXT combined with sodium hyaluronate can produce good therapeutic effects for patients with knee osteoarthritis, which can positively affect the synovial fluid inflammatory factors so that effectiveness of adjuvant treatment can be improved.Keywords
This publication has 18 references indexed in Scilit:
- IL-37 is associated with osteoarthritis disease activity and suppresses proinflammatory cytokines production in synovial cellsScientific Reports, 2017
- An overview of the role of lipid peroxidation-derived 4-hydroxynonenal in osteoarthritisInflammation Research, 2017
- An update on the pathophysiology of osteoarthritisAnnals of Physical and Rehabilitation Medicine, 2016
- Clinical comparison of oral administration and viscosupplementation of hyaluronic acid (HA) in early knee osteoarthritisMUSCULOSKELETAL SURGERY, 2016
- The minimal clinically important difference for Knee Society Clinical Rating System after total knee arthroplasty for primary osteoarthritisKnee Surgery, Sports Traumatology, Arthroscopy, 2016
- The role of resolvin D1 in the regulation of inflammatory and catabolic mediators in osteoarthritisInflammation Research, 2016
- A consensus statement on the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) algorithm for the management of knee osteoarthritis—From evidence-based medicine to the real-life settingSeminars in Arthritis and Rheumatism, 2015
- Cytokines as biochemical markers for knee osteoarthritisWorld Journal of Orthopedics, 2015
- Intraarticular injection of hyaluronan prevents cartilage erosion, periarticular fibrosis and mechanical allodynia and normalizes stance time in murine knee osteoarthritisArthritis Research & Therapy, 2011
- Joint fluid antioxidants are decreased in osteoarthritic joints compared to joints with macroscopically intact cartilage and subacute injuryOsteoarthritis and Cartilage, 2008