Screening-detected positive serology for celiac disease: a real clinical challenge
- 19 February 2021
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in European Journal of Gastroenterology & Hepatology
- Vol. 33 (1S), e999-e1002
- https://doi.org/10.1097/meg.0000000000002093
Abstract
According to European Society for Paediatric Gastroenterology, Hepatology, and Nutrition 2020 criteria for celiac disease diagnosis, the small bowel biopsy (SBB) can be omitted in selected circumstances, even in asymptomatic patients. Hence, we have conducted a retrospective study to identify the histological findings of the asymptomatic patients with antitransglutaminase IgA antibodies 10 times above the upper limit of normal and positive antiendomisium antibodies; 5/24 patients fulfilling these criteria had, however, a nonconclusive SBB and were diagnosed with potential celiac disease. The nonbiopsy approach in these cases needs to be carefully evaluated and the risk of overdiagnosis pondered as the management and evolution of potential celiac disease cases is still a matter of study.Keywords
This publication has 18 references indexed in Scilit:
- ESPGHAN 2012 Guidelines for Coeliac Disease DiagnosisJournal of Pediatric Gastroenterology and Nutrition, 2016
- Are ESPGHAN “Biopsy-Sparing” Guidelines for Celiac Disease also Suitable for Asymptomatic Patients?The American Journal of Gastroenterology, 2015
- Randomized Feeding Intervention in Infants at High Risk for Celiac DiseaseThe New England Journal of Medicine, 2014
- Introduction of Gluten, HLA Status, and the Risk of Celiac Disease in ChildrenThe New England Journal of Medicine, 2014
- Tricks of the trade: How to avoid histological Pitfalls in celiac diseasePathology - Research and Practice, 2012
- European Society for Pediatric Gastroenterology, Hepatology, and Nutrition Guidelines for the Diagnosis of Coeliac DiseaseJournal of Pediatric Gastroenterology and Nutrition, 2012
- Coeliac disease: a biopsy is not always necessary for diagnosisAlimentary Pharmacology & Therapeutics, 2008
- Immunoglobulin A autoantibodies against transglutaminase 2 in the small intestinal mucosa predict forthcoming coeliac diseaseAlimentary Pharmacology & Therapeutics, 2006
- In vivo targeting of intestinal and extraintestinal transglutaminase 2 by coeliac autoantibodiesGut, 2004
- The histopathology of coeliac diseaseEuropean Journal of Gastroenterology & Hepatology, 1999