Roadmap for metal nanoparticles in radiation therapy: current status, translational challenges, and future directions
- 7 May 2020
- journal article
- research article
- Published by IOP Publishing in Physics in Medicine & Biology
- Vol. 65 (21), 21RM02
- https://doi.org/10.1088/1361-6560/ab9159
Abstract
This roadmap outlines the potential roles of metallic nanoparticles (MNPs) in the field of radiation therapy. MNPs made up of a wide range of materials (from Titanium, Z=22, to Bismuth, Z=83) and a similarly wide spectrum of potential clinical applications, including diagnostic, therapeutic (radiation dose enhancers, hyperthermia inducers, drug delivery vehicles, vaccine adjuvants, photosensitizers, enhancers of immunotherapy) and theranostic (combining both diagnostic and therapeutic), are being fabricated and evaluated. This roadmap covers contributions from experts in these topics summarizing their view of the current status and challenges, as well as expected advancements in technology to address these challenges.Keywords
Funding Information
- Canadian Institute of Health Research (PJT-162325)
- German Research Foundation (RU 2197/1-1)
- NIH Clinical Center (R01EB020658)
- European Commission (ARGENT (FP7-PEOPLE-2013-ITN- 608163)
- Cancer Prevention and Research Institute of Texas (CPRIT RP170314)
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