Application Effect of Dexmedetomidine and Dezocine in Patients Undergoing Lung Cancer Surgery under General Anesthesia and Analysis of Their Roles in Recovery Time and Cognitive Function
Open Access
- 30 June 2022
- journal article
- research article
- Published by Hindawi Limited in Computational and Mathematical Methods in Medicine
- Vol. 2022, 1-8
- https://doi.org/10.1155/2022/9889534
Abstract
Application Effect of Dexmedetomidine and Dezocine in Patients Undergoing Lung Cancer Surgery under General Anesthesia and Analysis of Their Roles in Recovery Time and Cognitive Function: Objective. To explore the application influence of dexmedetomidine (DEX) and dezocine in patients undergoing lung cancer surgery under general anesthesia and analysis of their roles in recovery time and cognitive function. Methods. A total of 120 patients who accepted thoracoscopic pulmonary wedge resection in our hospital from November 2021 to April 2022 were selected and randomly divided into group A ( =60) and group B ( =60). DEX combined with dezocine-assisted anesthesia was performed to group A, and the equal dose of normal saline was administered to group B, so as to compare their inflammatory influence level, brain function, arterial blood gas index, and cognitive function. Results. Compared with group B, group A obtained significantly lower intraoperative and postoperative inflammatory factor levels ( ), better postoperative brain function and arterial blood gas index ( ), and lower Loewenstein Occupational Therapy Cognitive Assessment (LOTCA) scores after surgery ( )....Keywords
Funding Information
- Natural Science Foundation of Shanghai (21ZR1414000)
This publication has 24 references indexed in Scilit:
- Dexmedetomidine promotes metastasis in rodent models of breast, lung, and colon cancersBritish Journal of Anaesthesia, 2018
- Anesthetic management of off-pump simultaneous coronary artery bypass grafting and lobectomyMedicine, 2017
- Modelling the effects of perioperative interventions on cancer outcome: lessons from dexmedetomidineBritish Journal of Anaesthesia, 2017
- Effect of Oxycodone Combined With Dexmedetomidine for Intravenous Patient-Controlled Analgesia After Video-Assisted Thoracoscopic LobectomyJournal of Cardiothoracic and Vascular Anesthesia, 2016
- Effects of dexmedetomidine on oxygenation and lung mechanics in patients with moderate chronic obstructive pulmonary disease undergoing lung cancer surgeryEuropean Journal of Anaesthesiology, 2016
- The Use of Intraoperative Dexmedetomidine Is Not Associated With a Reduction in Acute Kidney Injury After Lung Cancer SurgeryJournal of Cardiothoracic and Vascular Anesthesia, 2016
- Dexmedetomidine Attenuates Bilirubin-Induced Lung Alveolar Epithelial Cell Death In Vitro and In Vivo*Critical Care Medicine, 2015
- Effects of dexmedetomidine pretreatment on heme oxygenase-1 expression and oxidative stress during one-lung ventilation.2015
- Efficacy of bevacizumab plus erlotinib versus erlotinib alone in advanced non-small-cell lung cancer after failure of standard first-line chemotherapy (BeTa): a double-blind, placebo-controlled, phase 3 trialThe Lancet, 2011
- Is small cell lung cancer the perfect target for anti-telomerase treatment?Carcinogenesis: Integrative Cancer Research, 1999