Prevalence of EBV, CMV, and HPV in oral squamous cell carcinoma patients in the Pakistani population

Abstract

Many studies have proposed an important role of viruses in the pathogenesis of oral cancer. The present study aimed to find out the prevalence of Epstein‐Barr virus (EBV), Cytomegalovirus (CMV) and Human Papillomavirus (HPV) among patients with oral squamous cell carcinoma (OSCC) in a Pakistani cohort. We investigated tissue samples obtained from 58 patients with OSCC using the polymerase chain reaction assay. No sample was positive for HPV. EBV was identified in 15 patients (25.86%), and CMV in 3 patients (5.17%). Coinfection with one or more viruses was detected in 2 cases and was co‐infection with EBV and CMV. These results suggest a low prevalence of these viruses in OSCC patients in the Pakistani population compared to most other countries where the prevalence of these viruses has been reported in the past. Nevertheless, further studies are necessary to determine the potential role of EBV and the possible importance of CMV as an infection co‐factor in oral cancer.