Comparison of 3-month visual outcomes of a new multifocal intraocular lens vs a trifocal intraocular lens

Abstract

Purpose: To compare clinical performance of TECNIS Synergy multifocal (model ZFR00V) intraocular lens (IOL) vs Acrysof PanOptix Trifocal (model TFNT00) IOL in patients undergoing bilateral cataract surgery. Setting: Multicenter clinical setting. Design: Prospective, randomized, comparative study. Methods: Patients aged ≥22 years were randomly assigned (2:1) to bilateral implantation with ZFR00V or TFNT00. Endpoints included mean binocular distance-corrected near visual acuity (DCNVA) at 40 cm, photopic and mesopic DCNVA at 33 cm, photopic low-contrast best corrected distance visual acuity (BCDVA) and mesopic BCDVA, nondirected patient responses to an ocular/visual symptoms questionnaire, and safety. Results: Of the 150 implanted patients, 95 of 97 patients with ZFR00V implants and 52 of 53 patients with TFNT00 implants completed the 3-month follow-up. Most patients in the ZFR00V and TFNT00 groups achieved 20/25 or better binocular BCDVA (100% vs 96.2%) and DCNVA measured at 40 cm (88.4% vs 75.0%) and 33 cm (78.9% vs 51.9%). The mean between-group difference in binocular DCNVA at 40 cm favored ZFR00V (0.5 lines Snellen; 95% CI, 0.012–0.089; P ≤ .05). Similarly, mean binocular photopic and mesopic DCNVA at 33 cm (0.8 lines Snellen each; both P ≤ .05 vs TFNT00) and photopic high- and low-contrast BCDVA (0.5 lines Snellen each; both P ≤ .05 vs TFNT00) favored ZFR00V. Patient-reported ocular/visual symptoms and safety were generally similar between the two IOLs. Conclusions: The ZFR00V IOL showed an extensive range of vision, particularly through near distances, and better mesopic performance versus TFNT00 IOL in patients undergoing cataract surgery.