Oestrogenic Endocrine Disruptors in the Placenta and the Fetus
Top Cited Papers
Open Access
- 22 February 2020
- journal article
- review article
- Published by MDPI AG in International Journal of Molecular Sciences
- Vol. 21 (4), 1519
- https://doi.org/10.3390/ijms21041519
Abstract
Endocrine disrupting chemicals (EDCs) are exogenous substances that interfere with the stability and regulation of the endocrine system of the body or its offspring. These substances are generally stable in chemical properties, not easy to be biodegraded, and can be enriched in organisms. In the past half century, EDCs have gradually entered the food chain, and these substances have been frequently found in maternal blood. Perinatal maternal hormone levels are unstable and vulnerable to EDCs. Some EDCs can affect embryonic development through the blood-fetal barrier and cause damage to the neuroendocrine system, liver function, and genital development. Some also effect cross-generational inheritance through epigenetic mechanisms. This article mainly elaborates the mechanism and detection methods of estrogenic endocrine disruptors, such as bisphenol A (BPA), organochlorine pesticides (OCPs), diethylstilbestrol (DES) and phthalates (PAEs), and their effects on placenta and fetal health in order to raise concerns about the proper use of products containing EDCs during pregnancy and provide a reference for human health.This publication has 119 references indexed in Scilit:
- Exposure Levels of Environmental Endocrine Disruptors in Mother-Newborn Pairs in China and Their Placental Transfer CharacteristicsPLOS ONE, 2013
- Bisphenol A Exposure Disrupts Genomic Imprinting in the MousePLoS Genetics, 2013
- Phytoestrogens in Human PregnancyObstetrics and Gynecology International, 2012
- Association between Pregnancy Loss and Urinary Phthalate Levels around the Time of ConceptionEnvironmental Health Perspectives, 2012
- Prenatal exposure to organochlorine pesticides and TSH status in newborns from Southern SpainScience of The Total Environment, 2011
- Cell Signaling by Receptor Tyrosine KinasesCell, 2010
- Endocrine-Disrupting Chemicals: An Endocrine Society Scientific StatementEndocrine Reviews, 2009
- Concentrations of Phthalate Metabolites in Milk, Urine, Saliva, and Serum of Lactating North Carolina WomenEnvironmental Health Perspectives, 2009
- Breast Cancer in Mothers Given Diethylstilbestrol in PregnancyThe New England Journal of Medicine, 1984
- A Twenty-Five-Year Follow-up Study of Women Exposed to Diethylstilbestrol during PregnancyThe New England Journal of Medicine, 1978