Spatially resolved single-cell genomics and transcriptomics by imaging
Top Cited Papers
- 6 January 2021
- journal article
- editorial
- Published by Springer Science and Business Media LLC in Nature Methods
- Vol. 18 (1), 18-22
- https://doi.org/10.1038/s41592-020-01037-8
Abstract
The recent advent of genome-scale imaging has enabled single-cell omics analysis in a spatially resolved manner in intact cells and tissues. These advances allow gene expression profiling of individual cells, and hence in situ identification and spatial mapping of cell types, in complex tissues. The high spatial resolution of these approaches further allows determination of the spatial organizations of the genome and transcriptome inside cells, both of which are key regulatory mechanisms for gene expression.Funding Information
- U.S. Department of Health & Human Services | National Institutes of Health
- Howard Hughes Medical Institute
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