Daylight photodynamic therapy with methyl aminolevulinate cream is as effective as conventional photodynamic therapy with blue light in the treatment of actinic keratosis: a controlled randomized intra‐individual study
- 19 January 2020
- journal article
- research article
- Published by Wiley in Journal of the European Academy of Dermatology and Venereology
- Vol. 34 (8), 1730-1735
- https://doi.org/10.1111/jdv.16208
Abstract
Background We know the efficacy of daylight phototherapy dynamic (DL‐PDT) in the treatment of actinic keratosis (AK). But the almost studies have compared daylight with red light using methylaminolevulinate cream and no with blue light. PDT with blue light is another conventional PDT that is effective in the treatment of AKs. Objectives The aim of this study is to assess the efficacy and the safety of DL‐PDT vs PDT in blue light in the treatment of AKs. Methods This randomised, controlled, intra‐individual efficacy and safety study enrolled 26 subjects. AKs on the face/scalp were treated once, with DL‐PDT on one side and c‐PDT on the contralateral side. Primary end points for DL‐PDT at week 12 were efficacy with clearance of AKs and safety with assessment of pain. Lesions with complete response 12 weeks after one treatment session were followed until week 24. Results More than 1000 AK were studied. At week 12, the raw number of disappeared AK lesions at 3‐month follow‐up was 19.6 (± 6.0) for DL‐PDT and 20.0 (± 6.9) for c‐PDT with p=0.8460 (90,5% vs 94,2% of AK disappearance respectively). The response was maintained at 6 months (90,0% and 94,6% of AK reduction respectively). DL‐PDT was nearly painless than c‐PDT with light blue: 1.2 vs 5.1 respectively (p<0.0001). Conclusions DL‐PDT seems as effective as c‐PDT with light blue and DL‐PDT is less painful. The response of DL‐PDT was sustainable until 6 monthsKeywords
Funding Information
- Galderma
This publication has 16 references indexed in Scilit:
- Conventional vs. daylight methyl aminolevulinate photodynamic therapy for actinic keratosis of the face and scalp: an intra‐patient, prospective, comparison study in ItalyJournal of the European Academy of Dermatology and Venereology, 2015
- Practical approach to the use of daylight photodynamic therapy with topical methyl aminolevulinate for actinic keratosis: a European consensusJournal of the European Academy of Dermatology and Venereology, 2015
- Update on Photodynamic Treatment for Actinic KeratosisCurrent problems in dermatology, 2014
- Daylight photodynamic therapy with methyl aminolevulinate cream as a convenient, similarly effective, nearly painless alternative to conventional photodynamic therapy in actinic keratosis treatment: a randomized controlled trialBritish Journal of Dermatology, 2014
- Correlation between Protoporphyrin IX Fluorescence Intensity, Photobleaching, Pain and Clinical Outcome of Actinic Keratosis Treated by Photodynamic TherapyDermatology, 2013
- Weather conditions and daylight-mediated photodynamic therapy: protoporphyrin IX-weighted daylight doses measured in six geographical locationsBritish Journal of Dermatology, 2012
- CONSORT 2010 statement: Updated guidelines for reporting parallel group randomised trialsInternational Journal of Surgery, 2011
- Continuous ultra‐low‐intensity artificial daylight is not as effective as red LED light in photodynamic therapy of multiple actinic keratosesPhotodermatology, Photoimmunology & Photomedicine, 2011
- A randomized, multicentre study of directed daylight exposure times of 1½ vs. 2½ h in daylight-mediated photodynamic therapy with methyl aminolaevulinate in patients with multiple thin actinic keratoses of the face and scalpBritish Journal of Dermatology, 2011
- Continuous activation of PpIX by daylight is as effective as and less painful than conventional photodynamic therapy for actinic keratoses; a randomized, controlled, single-blinded studyBritish Journal of Dermatology, 2008