A Common Missense Variant in OMA1 Associated with the Prognosis of Heart Failure
- 31 March 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Cardiovascular Drugs and Therapy
- Vol. 34 (3), 345-356
- https://doi.org/10.1007/s10557-020-06960-8
Abstract
Mitochondrial dysfunction plays a vital role in the pathophysiologic process of heart failure (HF). As a quality control system, mitochondrial fusion and fission are under control of mitochondrial fusion and fission-related proteins. The objective of this study was to investigate the effects of common variants in mitochondrial fusion and fission-related genes on the prognosis of HF.Keywords
Funding Information
- National Key R&D Program of China (NO.2017YFC0909400)
- National Program on Key Basic Research Project (No.2012CB518004)
- National Nature Science Foundation Key project (91439203, 81790624)
- National Precision Medicine Project (SQ2017YFSF090157)
This publication has 46 references indexed in Scilit:
- Novel approaches to the management of chronic systolic heart failure: future directions and unanswered questionsEuropean Heart Journal, 2019
- Heart failure drug treatmentThe Lancet, 2019
- Targeted OMA1 therapies for cancerInternational Journal of Cancer, 2019
- Mitochondrial Dynamics and Metabolic RegulationTrends in Endocrinology & Metabolism, 2016
- Mitochondrial dynamics, mitophagy and cardiovascular diseaseJournal Of Physiology-London, 2016
- Mitochondrial Dynamics and Heart FailurePublished by Wiley ,2015
- Mitochondrial fusion and fission proteins: novel therapeutic targets for combating cardiovascular diseaseBritish Journal of Pharmacology, 2014
- Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseasesHuman Molecular Genetics, 2009
- Genetic polymorphisms and heart failureGenetics in Medicine, 2004
- Genetic aspects of heart failure.European Journal of Heart Failure, 1999