Natural Polymer-Based Antimicrobial Hydrogels without Synthetic Antibiotics as Wound Dressings
Top Cited Papers
- 16 July 2020
- journal article
- review article
- Published by American Chemical Society (ACS) in Biomacromolecules
- Vol. 21 (8), 2983-3006
- https://doi.org/10.1021/acs.biomac.0c00760
Abstract
Wound healing is usually accompanied with bacterial infection. The excessive use of synthetic antibiotics leads to drug resistance, posing a significant threat to human health. Hydrogel-based wound dressing aimed at mitigating bacterial infections have emerged as an effective wound treatment. The review presented herein particularly focuses on the hydrogels originating from natural polymers. To further enhance the performance of wound dressings, various strategies and approaches have been developed to endow the hydrogels with excellent broad-spectrum antibacterial activity. The summarized in the current review are the hydrogels with intrinsic or stimuli-triggered bactericidal properties and others that serve as vehicles for loading antibacterial agents without synthetic antibiotics. Specific attention is paid to antimicrobial mechanisms and the antibacterial performance of hydrogels. Practical antibacterial applications to accelerate the wound healing employing these antibiotic-free hydrogels are also introduced along with the discussion on the current challenges and perspectives leading to new technologies.Keywords
Funding Information
- Ministry of Education of the People's Republic of China
- Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada
- National Natural Science Foundation of China (31730106)
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