Resveratrol and Cardiac Fibrosis Prevention and Treatment
- 1 February 2022
- journal article
- review article
- Published by Bentham Science Publishers Ltd. in Current Pharmaceutical Biotechnology
- Vol. 23 (2), 190-200
- https://doi.org/10.2174/1389201022666210212125003
Abstract
Cardiovascular diseases are some of the major causes of morbidity and mortality in developed or developing countries but in developed countries as well. Cardiac fibrosis is one of the most often pathological changes of heart tissues. It occurs as a result of extracellular matrix proteins accumulation at myocardia. Cardiac fibrosis results in impaired cardiac systolic and diastolic functions and is associated with other effects. Therapies with medicines have not been sufficiently successful in treating chronic diseases such as CVD. Therefore, the interest for therapeutic potential of natural compounds and medicinal plants has increased. Plants such as grapes, berries and peanuts contain a polyphenolic compound called "resveratrol" which has been reported to have various therapeutic properties for a variety of diseases. Studies on laboratory models that show that resveratrol has beneficial effects on cardiovascular diseases including myocardial infarction, high blood pressure cardiomyopathy, thrombosis, cardiac fibrosis, and atherosclerosis. In vitro animal models using resveratrol indicated protective effects on the heart by neutralizing reactive oxygen species, preventing inflammation, increasing neoangiogenesis, dilating blood vessels, suppressing apoptosis and delaying atherosclerosis. In this review, we are presenting experimental and clinical results of studies concerning resveratrol effects on cardiac fibrosis as a CVD outcome in humans.Keywords
This publication has 119 references indexed in Scilit:
- Transforming growth factor (TGF)-β signaling in cardiac remodelingJournal of Molecular and Cellular Cardiology, 2011
- The origin of fibroblasts and mechanism of cardiac fibrosisJournal of Cellular Physiology, 2010
- Resveratrol: Biological and pharmaceutical properties as anticancer moleculeBioFactors, 2010
- Targeting the PI3K signaling pathway in cancerCurrent Opinion in Genetics & Development, 2010
- Resveratrol Delays Age-Related Deterioration and Mimics Transcriptional Aspects of Dietary Restriction without Extending Life SpanCell Metabolism, 2008
- Cellular and molecular mechanisms of fibrosisThe Journal of Pathology, 2007
- The role of TGF-β signaling in myocardial infarction and cardiac remodelingCardiovascular Research, 2007
- Resveratrol improves health and survival of mice on a high-calorie dietNature, 2006
- Sirtuin activators mimic caloric restriction and delay ageing in metazoansNature, 2004
- Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespanNature, 2003