Dopamine modulation of learning and memory in the prefrontal cortex: insights from studies in primates, rodents, and birds
Open Access
- 5 August 2014
- journal article
- review article
- Published by Frontiers Media SA in Frontiers in Neural Circuits
- Vol. 8, 93
- https://doi.org/10.3389/fncir.2014.00093
Abstract
In this review, we provide a brief overview over the current knowledge about the role of dopamine transmission in the prefrontal cortex during learning and memory. We discuss work in humans, monkeys, rats, and birds in order to provide a basis for comparison across species that might help identify crucial features and constraints of the dopaminergic system in executive function. Computational models of dopamine function are introduced to provide a framework for such a comparison. We also provide a brief evolutionary perspective showing that the dopaminergic system is highly preserved across mammals. Even birds, following a largely independent evolution of higher cognitive abilities, have evolved a comparable dopaminergic system. Finally, we discuss the unique advantages and challenges of using different animal models for advancing our understanding of dopamine function in the healthy and diseased brain.Keywords
This publication has 155 references indexed in Scilit:
- Dopamine regulation of human speech and bird song: A critical reviewBrain and Language, 2012
- A hypothesis for basal ganglia-dependent reinforcement learning in the songbirdNeuroscience, 2011
- Differences between Neural Activity in Prefrontal Cortex and Striatum during Learning of Novel Abstract CategoriesNeuron, 2011
- Catecholamine Influences on Dorsolateral Prefrontal Cortical NetworksBiological Psychiatry, 2011
- Dopamine in Motivational Control: Rewarding, Aversive, and AlertingNeuron, 2010
- Dynamic Network Connectivity: A new form of neuroplasticityTrends in Cognitive Sciences, 2010
- Mapping gray matter development: Implications for typical development and vulnerability to psychopathologyBrain and Cognition, 2010
- Dopamine receptors in a songbird brainJournal of Comparative Neurology, 2009
- Learning Substrates in the Primate Prefrontal Cortex and Striatum: Sustained Activity Related to Successful ActionsNeuron, 2009
- The Yin and Yang of dopamine release: a new perspectiveNeuropharmacology, 2007