Endothelium-targeted deletion of the miR-15a/16-1 cluster ameliorates blood-brain barrier dysfunction in ischemic stroke
- 7 April 2020
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science Signaling
- Vol. 13 (626)
- https://doi.org/10.1126/scisignal.aay5686
Abstract
Targeting of Claudin-5 by a microRNA cluster may contribute to blood-brain barrier leakage after stroke.Keywords
Funding Information
- National Institutes of Health (NS091175, NS094930, NS08682)
This publication has 52 references indexed in Scilit:
- Inhibition of MicroRNA‐155 Supports Endothelial Tight Junction Integrity Following Oxygen‐Glucose DeprivationJournal of the American Heart Association, 2018
- Early Blood-Brain Barrier Disruption in Ischemic Stroke Initiates Multifocally Around Capillaries/VenulesStroke, 2018
- MicroRNA‐130a regulates cerebral ischemia–induced blood–brain barrier permeability by targeting Homeobox A5The FASEB Journal, 2018
- Rapid endothelial cytoskeletal reorganization enables early blood–brain barrier disruption and long-term ischaemic reperfusion brain injuryNature Communications, 2016
- Establishment and Dysfunction of the Blood-Brain BarrierCell, 2015
- Angiogenesis-regulating microRNAs and Ischemic StrokeCurrent Vascular Pharmacology, 2015
- MiR-181a Regulates Blood-Tumor Barrier Permeability by Targeting Krüppel-Like Factor 6Journal of Cerebral Blood Flow & Metabolism, 2014
- Epileptiform Activity Induces Vascular Remodeling and Zonula Occludens 1 Downregulation in Organotypic Hippocampal Cultures: Role of VEGF Signaling PathwaysJournal of Neuroscience, 2011
- Astrocyte–endothelial interactions at the blood–brain barrierNature Reviews Neuroscience, 2006
- Size-selective loosening of the blood-brain barrier in claudin-5–deficient miceThe Journal of cell biology, 2003