Fragment‐Based Discovery of Non‐bisphosphonate Binders of Trypanosoma brucei Farnesyl Pyrophosphate Synthase
Open Access
- 14 June 2020
- journal article
- research article
- Published by Wiley in ChemBioChem
- Vol. 21 (21), 3096-3111
- https://doi.org/10.1002/cbic.202000246
Abstract
Fluorophores are greatly influenced by their environment . In their full paper, L. Cui et al. show that triggering the aggregation of a self‐condensing scaffold labeled with a fluorophore induces changes in the emission spectrum, polarization, and lifetime. The aggregates exhibited a shorter lifetime detectable in cells by fluorescence lifetime imaging microscopy, thus suggesting that triggered aggregation strategies can be used in the probes for various biological events through lifetime imaging.Keywords
Funding Information
- H2020 Marie Skłodowska-Curie Actions (FRAGNET (project 675899), AEGIS (project 765555))
- H2020 Research Infrastructures (iNEXT (H2020 Grant 653706))
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