The design of cyclometalated iridium(III)-metformin complexes for hypoxic cancer treatment
- 27 January 2021
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- Vol. 57 (9), 1093-1096
- https://doi.org/10.1039/d0cc07104h
Abstract
Modulating the hypoxic microenvironment is the priority for tumor treatment. Cytometalated iridium(III)-metformin conjugates were synthesized for treating hypoxic cancer cells for the first time, which alleviate hypoxia via mitochondria respiration inhibition, thus displaying 10-fold higher cytotoxicity, emerging anti-metastasis and anti-inflammatory activities than a metformin-free Ir(III) complex and cisplatin against hypoxic cancer cells.Funding Information
- National Natural Science Foundation of China (21401217, 21837006, 22067011, 91953117)
- Science and Technology Planning Project of Guangdong Province (2013B051000047, 2019A1515011908, 207999)
- Fundamental Research Funds for the Central Universities
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