A new therapeutic horizon in diaper dermatitis: Novel agents with novel action
Open Access
- 1 September 2021
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in International Journal of Women’s Dermatology
- Vol. 7 (4), 466-470
- https://doi.org/10.1016/j.ijwd.2021.02.003
Abstract
This review looks at novel combinations of topical agents (i.e., zinc gluconate, zinc oxide, dexpanthenol, and taurine) that target a combination of mechanisms in diaper dermatitis. A literature search of published studies was conducted using the search terms "diaper dermatitis", "treatment of diaper dermatitis in infants", "treatment of diaper dermatitis in adults", "nonsteroidal", "nonantibiotic", "antiinflammatory", "moisturizer", and "treatment for irritation". A total of 207 related articles were screened, and those categorized as clinical trials and reviews were studied and compared. Articles with common themes were categorized, summarized, and presented herein. Diaper dermatitis, also referred to as diaper rash, napkin dermatitis, and nappy rash, is the most common skin eruption in infants and toddlers. In the last several years, there have been several technologic advances in diaper design to lessen the severity of diaper dermatitis symptoms. However, due to the unique environment of the diaper area, children and adults continue to have recurring symptoms of diaper dermatitis. Both commercially available products and certain home remedies are considered effective for managing sensitive and delicate skin in the diaper area. These topical agents create a protective barrier over the skin and reduce the impact of external irritants, which cause the reddening and burning sensation often associated with diaper dermatitis. A range of therapeutic strategies for preventing and controlling diaper dermatitis are summarized in this manuscript.Keywords
This publication has 21 references indexed in Scilit:
- Zinc Therapy in Dermatology: A ReviewDermatology Research and Practice, 2014
- Efficacy of petrolatum jelly for the prevention of diaper rash: A randomized clinical trialJournal for Specialists in Pediatric Nursing, 2013
- Taurine and inflammatory diseasesAmino Acids, 2012
- Effect on skin hydration of using baby wipes to clean the napkin area of newborn babies: assessor-blinded randomised controlled equivalence trialBMC Pediatrics, 2012
- A Randomized Comparative Trial on the Therapeutic Efficacy of TopicalAloe veraandCalendula officinalison Diaper Dermatitis in ChildrenThe Scientific World Journal, 2012
- Effect of the Topical Use of the Antioxidant Taurine on the Two Basement Membrane Proteins of Regenerating Oral Gingival EpitheliumThe Journal of Periodontology, 2012
- Improving diaper design to address incontinence associated dermatitisBMC Geriatrics, 2010
- Role of Taurine Accumulation in Keratinocyte HydrationJournal of Investigative Dermatology, 2003
- Continuous Topical Administration of a Petrolatum Formulation by a Novel Disposable DiaperDermatology, 2000
- Continuous Topical Administration of a Petrolatum Formulation by a Novel Disposable DiaperDermatology, 2000