Antibody response patterns in COVID‐19 patients with different levels of disease severity in Japan
Open Access
- 23 February 2021
- journal article
- research article
- Published by Wiley in Journal of Medical Virology
- Vol. 93 (5), 3211-3218
- https://doi.org/10.1002/jmv.26899
Abstract
We analyzed antibody response patterns according to the level of disease severity in patients with novel coronavirus disease 2019 (COVID‐19) in Japan. We analyzed 611 serum specimens from 231 patients with COVID‐19 (mild, 170; severe, 31; critical, 30). Immunoglobulin M (IgM) and IgG antibodies against nucleocapsid protein (N) and spike 1 protein (S1) were detected by enzyme‐linked immunosorbent assays. The peaks of fitting curves for the optical density (OD) values of IgM and IgG antibodies against N appeared simultaneously, while those against S1 were delayed compared with N. The OD values of IgM against N and IgG against both N and S1 were significantly higher in the severe and critical cases than in the mild cases at 11 days after symptom onset. The seroconversion rates of IgG were higher than those of IgM against both N and S1 during the clinical course based on the optimal cut‐off values defined in this study. The seroconversion rates of IgG and IgM against N and S1 were higher in the severe and critical cases than in the mild cases. Our findings show that a stronger antibody response occurred in COVID‐19 patients with greater disease severity and there were low seroconversion rates of antibodies against N and S1 in the mild cases.This publication has 26 references indexed in Scilit:
- Development of Genetic Diagnostic Methods for Detection for Novel Coronavirus 2019(nCoV-2019) in JapanJapanese Journal of Infectious Diseases, 2020
- Severe Acute Respiratory Syndrome Coronavirus 2−Specific Antibody Responses in Coronavirus Disease PatientsEmerging Infectious Diseases, 2020
- Projecting the transmission dynamics of SARS-CoV-2 through the postpandemic periodScience, 2020
- Human monoclonal antibodies block the binding of SARS-CoV-2 spike protein to angiotensin converting enzyme 2 receptorCellular & Molecular Immunology, 2020
- Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in ChinaJAMA, 2020
- Clinical features of patients infected with 2019 novel coronavirus in Wuhan, ChinaThe Lancet, 2020
- Antibody-dependent enhancement of severe dengue disease in humansScience, 2017
- Evaluation of diagnostic tests: dengueNature Reviews Microbiology, 2010
- Epitopes Required for Antibody‐Dependent Enhancement of Ebola Virus InfectionThe Journal of Infectious Diseases, 2007