Association among daily fish intake, white blood cell count, and healthy lifestyle behaviors in an apparently healthy Japanese population: implication for the anti-atherosclerotic effect of fish consumption
- 7 January 2021
- journal article
- research article
- Published by Springer Science and Business Media LLC in Heart and Vessels
- Vol. 36 (7), 924-933
- https://doi.org/10.1007/s00380-020-01769-9
Abstract
Higher fish consumption has been reported to be associated with a lower incidence of coronary artery disease. We hypothesized that a higher frequency of fish intake may be associated with lower peripheral white blood cell (WBC) counts, a marker of chronic inflammation, which is known to be involved in the development of atherosclerotic cardiovascular disease (ASCVD), and a healthy lifestyle. This cross-sectional study was conducted between April 2018 and August 2018 at the Health Planning Center of Nihon University Hospital in a cohort of 4105 apparently healthy subjects. The average frequency of fish intake was 2.3 ± 1.3 days per week. The WBC count decreased significantly as the frequency of fish intake (0–2 days, 3–4 days, or 5–7 days per week) increased (s < 0.0001). Multivariate linear regression analysis identified higher weekly frequency of fish intake as a significant independent determinant of a lower WBC count (β = – 0.051, p = 0.001). Furthermore, as the weekly frequency of fish intake increased, the proportion of habitual cigarette smokers decreased (p = 0.021), that of subjects engaging in habitual aerobic exercises increased (p < 0.0001), and the weekly alcohol intake frequency increased (p < 0.0001). Moreover, the above-mentioned lifestyle behaviors were also independent determinants of the WBC count. These results suggest that a high frequency of fish intake might be associated with healthier lifestyle behaviors as well as lower WBC counts, and thus may both exert beneficial anti-inflammatory effects and represent a component of healthier lifestyle behaviors associated with a lower risk of ASCVD in Japanese. This association may be partially related to the preventive effects of a higher fish intake on ASCVD events. Clinical Trial Registration UMIN (http://www.umin.ac.jp/) Study ID: UMIN000039197 retrospectively registered 1 February 2020.Keywords
This publication has 37 references indexed in Scilit:
- Diet and lifestyle factors associated with fish consumption in men and women: a study of whether gender differences can result in gender-specific confoundingNutrition Journal, 2012
- Omega-3 Fatty Acids and Cardiovascular Disease: Effects on Risk Factors, Molecular Pathways, and Clinical EventsJournal of the American College of Cardiology, 2011
- Serotonin control of sleep-wake behaviorSleep Medicine Reviews, 2011
- Revised Equations for Estimated GFR From Serum Creatinine in JapanAmerican Journal of Kidney Diseases, 2009
- Evaluation of relative intake of fatty acids according to the Northern Sweden FFQ with fatty acid levels in erythrocyte membranes as biomarkersPublic Health Nutrition, 2009
- Explanation for the Japanese Paradox: Prevention of Increase in Coronary Heart Disease and Reduction in StrokeJournal of Atherosclerosis and Thrombosis, 2007
- Association of white blood cell count with systolic blood pressure within the normotensive rangeJournal of Human Hypertension, 2006
- Markers of Inflammation and Cardiovascular DiseaseCirculation, 2003
- The MOS 36-Item Short-Form Health Survey (SF-36)Medical Care, 1993
- The Inverse Relation between Fish Consumption and 20-Year Mortality from Coronary Heart DiseaseThe New England Journal of Medicine, 1985