Laryngeal Helicobacter pylori Infection and Laryngeal Cancer-Case Series and a Systematic Review
Open Access
- 23 May 2021
- journal article
- review article
- Published by MDPI AG in Microorganisms
- Vol. 9 (6), 1129
- https://doi.org/10.3390/microorganisms9061129
Abstract
Helicobacter pylori (H. pylori) infection involves the development of gastric cancer and may be associated with laryngeal cancer. However, laryngeal H. pylori infection in Taiwanese patients with newly diagnosed laryngeal cancer has not been reported. This study was aimed to investigate the possible association between laryngeal H. pylori infection and laryngeal cancer in Taiwan and perform a systematic review of previous reports in other countries. An analysis of 105 patients with laryngeal lesions found the positive rates of H. pylori DNA (determined by polymerase chain reaction) and antigen (determined by immunohistochemistry) of the laryngeal lesions were relatively low (vocal polyps: 3% and 3%; vocal fold leukoplakia: 0% and 0%; laryngeal cancers: 0% and 2%). Furthermore, H. pylori-associated laryngopharyngeal reflux and the expression of E-cadherin and CD1d (determined by immunohistochemistry) were comparable among the three subgroups. Fifteen studies were involved in the systematic review of the digital literature database, distributed to February 2021. The data of patients with laryngeal cancer and controls showed that the laryngeal H. pylori infection rates were 29.4% and 16.7%, respectively. Although current evidence supported that laryngeal H. pylori infection was associated with laryngeal cancer globally, it might not play a role in the development of laryngeal cancer in Taiwan.Keywords
Funding Information
- Chang Gung Medical Foundation (3C0661–3 and 3F1091–3)
This publication has 73 references indexed in Scilit:
- Association between infection of virulence cagA gene Helicobacter pylori and laryngeal squamous cell carcinomaMedical Science Monitor, 2013
- The Role ofH. pyloriin the Development of Laryngeal Squamous Cell CarcinomaDisease Markers, 2013
- Association between Helicobacter pylori Infection and Laryngeal Squamous Cell Carcinoma in a Chinese Male PopulationORL, 2011
- The Role of Laryngopharyngeal Reflux as a Risk Factor in Laryngeal Cancer: A Preliminary ReportClinical and Experimental Otorhinolaryngology, 2011
- The Mucosal Immune Response to Laryngopharyngeal RefluxAmerican Journal of Respiratory and Critical Care Medicine, 2008
- E-cadherin promoter hypermethylation induced by interleukin-1β treatment or H. pylori infection in human gastric cancer cell linesCancer Letters, 2008
- Association between Helicobacter pylori infection and interleukin 1 polymorphism predispose to CpG island methylation in gastric cancerGut, 2007
- TOWARD AN UNDERSTANDING OF NKT CELL BIOLOGY: Progress and ParadoxesAnnual Review of Immunology, 2005
- Risk factors for laryngeal cancerEuropean Journal of Epidemiology, 1995